The functional structure

In localization theoriesn, local areas fulfill functions. Neurons conduct the excitations, and astrocytes assist and perform auxiliary tasks. Brain functions are realized in the interconnectedness of many areas. This is the current view of the functional brain structure.

The diagrams of the connectome chow something completely different. Countless fibers show the course of the excitations. Area boundaries and astrocytes are missing. The excitations run along predefined pathways from the receptors toward the target organs. In this delicate structure, the connectome fibers are the functional parts. This contradicts previous views of the functional brain structure. The astrocytes are located between.

The AI is changing brain research. The many astrocytes do more than just help.

If these fibers themselves realize the functions, the result is:

  1. Now there are millions of functional parts
  2. This structure is extremely delicate and consists of connected neurons
  3. The astrocytes do not act within, but between, the connectome fibers. This allows for a theory about the function of astrocytes. Finally, their number and activity can be interpreted. The function of the many astrocytes thus becomes understandable. Previous explanations of astrocytes are weak. Other cells perform the auxiliary tasks themselves; no additional extra cell is needed. The neuron cannot evaluate its own activity.
  4. This is a paradigm shift from previous classifications! A comparison: "Not seeing the forest for the trees (connectome fibers)."
  5. For each engram there is a special connectome fiber
  6. The flexibility of the brain is achieved through the many independent fibers
  7. Since an astrocyte feeds multiple fibers, they must share the nutrients. If one neuron or fiber consumes a lot, the others consume less. Text copied from here to there.
  8. In this way, the astrocytes can optimize the supplied fibers and their connections through nutrient supply.
  9. Engrams are changed unnoticed. We have a powerful helper within us: the astrocyte system. Completely new connections and thus engrams can emerge.
  10. In the previous classification, astrocytes perform auxiliary functions, serving as servants to the neurons. In the classification into functional connectome fibers, the neurons are the workers, and the astrocytes command and control the neurons actions.
  11. If connectome fibers shape excitations in a very delicate way with all their convergence and divergence, this does not fit with the evolution of mutation and selection (Darwin). If the differentiation of connectome fibers correlates with evolution, this would be a massive paradigm shift (Lamarck). Engrams are visible in the synaptic connections.

The psychology of perception is explained in the journal Spektrum 2/2024 using networks of connected neurons. The details described fit well with the properties of connectome fibers.



Comparison of functional divisions

Area Division
The previous division into functional areas

It's understandable to look for the brain's functions in locally definable areas. Unlike machines, the functional blueprint was/is unknown. The recognized structure is used to infer its function(s). This gives rise to numerous localization theories. And these have shaped thinking for over 2,000 years (literature: Localization Theories from Antiquity to the Present by Edwin Clarke/Kenneth Dewhurst). A Google search for "brain functional organization" reveals structural parts. Why is this error unnoticed?

Despite immense efforts, we have not succeeded in understanding the brain's functions. A.M. Wejn's research into the nonspecific brain systems already demonstrates the dead end of localization. In the localized classification, the functional parts consist of neural tissue, i.e., of intermingled neurons and astrocytes. The neurons do, and the astrocytes help; they are auxiliary cells.

Local theories have a major shortcoming. An area or a group of cells has far too few synaptic inputs to be able to make global decisions. This is well formulated in the Wikipedia article Mirror neuron: A neuron may be networked in many different ways, but it is not an intelligent agent (homunculus). Highly complex things, such as the intentions of others, can only be represented in neural networks that are at least as comple

Structure
The Connectome shows a different structure.


With this structure, the so-called structural structure, it is quite understandable that the countless fibers are functionally concentrated in certain places. The connected neurons have to go somewhere structurally. But these nuclei and areas are structural. In local structures, at most, fragments of a functional part become visible, and fibers for other functions also run through them. Here are similar considerations.
The structural organization does not have the disadvantage of a lack of input information. The number of areas is manageable; the number of connectome fibers is not. This is the only way objects/faces, etc., can be recognized extremely quickly. But these pre-formed pathways appear inflexible. Thesis: The flexibility is achieved by the many astrocytes, see
Why is this not accepted? Can't you see the forest for the trees?

Known details about astrocytes

Most cells in the brain are astrocytes. These not only perform auxiliary functions but also influence neurons.
The impulses travel through the brain at lightning speed. This happens via synaptically connected neurons. Astrocytes act in the background and at a slower pace. The following properties are unclear:

  1. The neurons are not supplied directly, but via the astrocytes.
  2. Although the nutrient reserves in the brain are small (this is explained by lack of space), there are huge numbers of astrocytes.
  3. One astrocyte nourishes several neurons and one neuron is nourished by several astrocytes
  4. Astrocytes not only nourish neighboring neurons, but also have supply pathways to distant neurons. I know of no other explanation/thesis for this fact.
  5. Astrocytes change their supply pathways during memory changes.
  6. The flexibility of the brain is realized locally in the interaction between neurons and glial cells. There is no central control center in the brain that controls everything.
  7. Flexikon, astrocytes evaluate and modulate neuronal activity.
  8. Nutrition via astrocytes is inferred to be a function of the blood-brain barrier. But this is weak. Much can pass through and disrupts the neurons.
  9. Neurons without contacts to the astrocytes behave helplessly and atrophy.

Gliathesis

A general law of division of labor/function is at work. The activity of one part affects the other functional parts. In the market economy, this becomes visible through accounting (Adam Smith calls this the invisible hand). Every activity in a division of labor/function changes the balance. Every activity in a division of labor/function changes the balance. Jede Tätigkeit in einer Arbeits-/Funktionsteilung verändert das Gleichgewicht. Every activity in a division of labor/function changes the balance sheet. Jede Tätigkeit in einer Arbeits-/Funktionsteilung verändert die Bilanz. The other functional parts benefit or disadvantage from this. This allows them to evaluate the respective action. In the brain, astrocytes register the energy consumption of the neurons they supply via many small channels and can thus influence their actions.
This is the actual function of astrocytes!

  1. The astrocytes not only nourish but also register the nutrient needs of the supplied neurons.
  2. Not one or neighboring neuron is supplied (which would be effective and space-saving), but functionally dependent neurons.
  3. With memory, functional dependencies also change. Astrocyte beams are adapted.
  4. Optimization via the energy balance can only be effective when reserves are limited. This is why reserves are so limited, and they are not evenly distributed. Thesis: Where flexibility is required, reserves are particularly limited.
  5. Neurons respond sensitively to "commands" from astrocytes. Astrocytes give the order, and neurons follow. Source: Medical Encyclopedia
  6. With these thoughts, the astrocytes do not form a barrier, but rather distribute nutrients in a targeted manner.
  7. A generally valid thermodynamic law is used: Every action changes the energy balance. Using this balance, an action can be evaluated. A mistake results in additional energy expenditure.

5. Impressum in german

Ich kann versichern, dass die obigen Gedanken mein Eigentum sind. Die andere Funktion ergab sich aus erlebten Widersprüchen im Arealdenken (hier Ratio, dort Gefühl). Jedes Engramm, jede Fähigkeit erzeugt Gefühle. Psychische Aktivität wird quer durch und nicht in lokalen Arealen generiert. Dieses Umdenken begann im Jahr 1976 in Bad Langensalza (Thüringen). Den Begriff "Straktur" hat Prof. Armin Ermisch, Hirnforscher in Leipzig, im Jahr 1983 vorgeschlagen. Lokal abgrenzbare Strukturen sind eben nicht sogleich funktionelle Teile. Deshalb der neue Begriff Straktur. Im Jahr 1976 war von der Netzwerkgliederung (Konnektom) noch nichts zu lesen. Die logischen Folgerungen aus der neuen Gliederung sind immens, z.B. Brief von Dr. Lothar Sprung Die These zur eigentlichen Funktion der Astrozyten ist nur ein kleiner Teil davon. Bekanntes Wissen wird wie bei einem Puzzle neu einsortiert.


2007
Diplom-Mathematiker
Stefan Pschera
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